abstract：PURPOSE:To determine the influence of race on breast cancer treatment and on recurrence and breast cancer specific death. PATIENTS AND METHODS:The study population consisted of 6,054 African-American or white women who were diagnosed with breast cancer and received at least one of the treatments including mastectomy o...

journal_title：Breast cancer research and treatment

authors： Shen Y,Dong W,Esteva FJ,Kau SW,Theriault RL,Bevers TB

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The aim was to prove the low identification rate of sentinel lymph node biopsy (SNB) and to determine the feasibility of replacing axillary lymph node dissection (AND) in axillary lymph node positive patients after chemotherapy. METHODS:From October 2001 to July 2005, 875 consecutive patients with primary o...

journal_title：Breast cancer research and treatment

authors： Lee S,Kim EY,Kang SH,Kim SW,Kim SK,Kang KW,Kwon Y,Shin KH,Kang HS,Ro J,Lee ES

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:Axillary node fine needle aspiration cytology (FNAC) has the potential to triage women with operable breast cancer to initial nodal surgical procedure. Because of variability in the reported accuracy of this test its role and clinical utility in pre-operative staging remains controversial. METHODS:We retr...

journal_title：Breast cancer research and treatment

authors： Ciatto S,Brancato B,Risso G,Ambrogetti D,Bulgaresi P,Maddau C,Turco P,Houssami N

更新日期：2007-05-01 00:00:00

abstract：:Conflicting theories of epithelial carcinogenesis disagree on the clonal composition of primary tumors and on the time at which metastases occur. In order to study the spatial distribution of disparate clonal populations within breast carcinomas and the extent of the genetic relationship between primary tumors and reg...

journal_title：Breast cancer research and treatment

authors： Torres L,Ribeiro FR,Pandis N,Andersen JA,Heim S,Teixeira MR

更新日期：2007-04-01 00:00:00

abstract：:The regulation of gene expression by steroid hormones plays an important role in the normal development and function of many organs, as well in the pathogenesis of endocrine-related cancers. Previous experiments have shown that many kallikrein genes are under steroid hormone regulation in breast cancer cell lines. We ...

journal_title：Breast cancer research and treatment

authors： Paliouras M,Diamandis EP

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women. METHODS:Cases (n = 2,325) diagnosed with breast cancer between October 1, 1999 and May 2004 residing in Arizona, Colorado, New Mexico, or ...

journal_title：Breast cancer research and treatment

authors： Slattery ML,Sweeney C,Edwards S,Herrick J,Baumgartner K,Wolff R,Murtaugh M,Baumgartner R,Giuliano A,Byers T

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:A recent SEER study identified significant variations in the care of women with DCIS, yet several potential confounding variables were not included. We report a patterns of care study of women with DCIS to better understand the gap between evidence-based knowledge and the management of DCIS. METHODS:We stud...

journal_title：Breast cancer research and treatment

authors： Rakovitch E,Pignol JP,Chartier C,Hanna W,Kahn H,Wong J,Mai V,Paszat L

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:The national guidelines recommend more intensive screening for breast cancer for women with a family history of breast or ovarian cancer. Using the data from the 2000 National Health Interview Survey (NHIS), we examined factors related to the underuse of mammogram in this population. METHOD:The study subject...

journal_title：Breast cancer research and treatment

authors： Wu H,Zhu K,Jatoi I,Shah M,Shriver CD,Potter J

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The genes mutated in the cancer-prone syndrome, xeroderma pigmentosum (XP genes), have been well studied both biochemically and mechanistically. These genes are important components of the DNA nucleotide excision repair (NER) pathway, which protects against environmentally-induced cancers. XP genes are also ...

journal_title：Breast cancer research and treatment

authors： Jorgensen TJ,Visvanathan K,Ruczinski I,Thuita L,Hoffman S,Helzlsouer KJ

更新日期：2007-01-01 00:00:00

abstract：:Long-term estrogen deprivation treatment for breast cancer can, in some patients, lead to the activation of alternate cellular pathways, resulting in the re-emergence of the disease. This is a distressing scenario for oncologists and patients, but recent intensive molecular and biochemical studies are beginning to unr...

journal_title：Breast cancer research and treatment

authors： Ellis M,Ma C

更新日期：2007-01-01 00:00:00

abstract：:25-Hydroxy-3-oxoolean-12-en-28-oic acid (Amooranin-AMR) is a triterpene acid isolated from the stem bark of a tropical tree (Amoora rohituka) grown wild in India. A herbal preparation used for the treatment of cancer by the Ayurvedic system of medicine contains the stem bark of Amoora rohituka as one of the ingredient...

journal_title：Breast cancer research and treatment

authors： Rabi T,Wang L,Banerjee S

更新日期：2007-01-01 00:00:00

abstract：:Tamoxifen has been a standard first-line endocrine therapy for post-menopausal women with hormone-responsive advanced breast cancer, but more than half of patients fail to respond and time to progression is less than 12 months in responders. The third-generation aromatase inhibitors were developed to provide more effe...

journal_title：Breast cancer research and treatment

authors： Mouridsen HT

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Improvements in the life expectancy of women with breast cancer raise important questions how to improve quality of life (QoL) for women sustaining complications and side effects of cancer treatment. The presented study examined the prevalence of arm morbidity in a cohort of primary breast cancer patients ov...

journal_title：Breast cancer research and treatment

authors： Albert US,Koller M,Kopp I,Lorenz W,Schulz KD,Wagner U

更新日期：2006-12-01 00:00:00

abstract：:Tumor formation can result from a decrease in cell death, as well as an increase in cell proliferation. In spite of the high incidence of mammary gland tumors (MGTs) in female dogs, the understanding of its etiology is still poor. Consistent with several proto-oncogenes (such as Wnt) for the mammary gland, sFRP2 is ex...

journal_title：Breast cancer research and treatment

authors： Lee JL,Chang CJ,Chueh LL,Lin CT

更新日期：2006-11-01 00:00:00

abstract：:Familial aggregations of breast/ovarian cancer cases frequently depend on BRCA1/2 pathogenic mutations. Here we counselled 120 Italian breast/ovarian cancer families and selected 73 probands for BRCA1/2 mutation screening. Through this analysis we defined the prevalence of BRCA1/2 pathogenic mutations occurring in Ita...

journal_title：Breast cancer research and treatment

authors： Giannini G,Capalbo C,Ristori E,Ricevuto E,Sidoni T,Buffone A,Cortesi E,Marchetti P,Scambia G,Tomao S,Rinaldi C,Zani M,Ferraro S,Frati L,Screpanti I,Gulino A

更新日期：2006-11-01 00:00:00

abstract：:The aim of this study was to assess the intensity of diagnostic testing and cancer treatment of 335 women with advanced breast cancer during their last 6 months before death between 1995 and 1998 in the Pirkanmaa and Satakunta health care districts and to compare it to the practice in earlier decades, the 1970s and 19...

journal_title：Breast cancer research and treatment

authors： Asola R,Huhtala H,Holli K

更新日期：2006-11-01 00:00:00

abstract：:This study was undertaken with regard to the gonadotropin theory of ovarian cancer advocated in the literature and was designed to disclose specific features of ovarian morphology in carriers of the BRCA1 gene mutation. We enrolled 171 patients and divided them into two groups: A (n=90)--operated for breast cancer (30...

journal_title：Breast cancer research and treatment

authors： Rzepka-Górska I,Tarnowski B,Chudecka-Głaz A,Górski B,Zielińska D,Tołoczko-Grabarek A

更新日期：2006-11-01 00:00:00

abstract：:Breast cancer has emerged as the most frequent malignancy among Korean women. Its clinical features have become closer to those now observed in Western countries. We performed this study to evaluate the chronological changes in Korean breast cancer characteristics and reproductive factors from 1996 to 2004. A nationwi...

journal_title：Breast cancer research and treatment

authors： Ahn SH,Yoo KY,Korean Breast Cancer Society.

更新日期：2006-09-01 00:00:00

abstract：:A novel human mammary epithelial cell line, HME348, was established from benign breast tissue from a 44-year-old germ-line BRCA2 mutation carrier with a history of stage 1 breast cancer. Mutation analysis showed that the patient had a known 6872del4 BRCA2 heterozygous mutation. The human mammary epithelial cells passa...

journal_title：Breast cancer research and treatment

authors： Lewis CM,Herbert BS,Bu D,Halloway S,Beck A,Shadeo A,Zhang C,Ashfaq R,Shay JW,Euhus DM

更新日期：2006-09-01 00:00:00

abstract：:We report the establishment of a breast epithelial cell model that undergoes growth arrest at different stages of the cell cycle depending upon the DNA damaging agents encountered. Primary breast epithelial cells from normal reductive mammoplasty were grown in low-calcium culture medium. Free-floating cells under this...

journal_title：Breast cancer research and treatment

authors： Shen KC,Miller F,Tait L,Santner SJ,Pauley R,Raz A,Tainsky MA,Brooks SC,Wang YA

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To determine whether fruit, vegetable, and micronutrient intake 1 year prior to breast cancer diagnosis is associated with a reduction in the subsequent risk of all-cause or breast cancer-specific mortality. METHODS:Follow-up data from 1,235 invasive breast cancer cases age 25-98 years from the Long Island B...

journal_title：Breast cancer research and treatment

authors： Fink BN,Gaudet MM,Britton JA,Abrahamson PE,Teitelbaum SL,Jacobson J,Bell P,Thomas JA,Kabat GC,Neugut AI,Gammon MD

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:The significance of HER-2/neu results obtained by immunohistochemical analyses (IHC) which are neither negative nor strongly positive is controversial. The incidence of fluorescence in situ hybridization (FISH) positivity in these tumors is small and the implication is that these borderline results represent la...

journal_title：Breast cancer research and treatment

authors： Killeen JL,Ortega-Lopez A,Shaha J,Shaha SH,Fu JB

更新日期：2006-07-01 00:00:00

abstract：:There are suggestions in the literature that common variants in the XPD gene may be associated with an altered risk of melanoma and breast cancer. To establish if the XPD common variants Asp312Asn and Lys751Gln are associated with an increased melanoma or breast cancer risk we performed an association study based on g...

journal_title：Breast cancer research and treatment

authors： Debniak T,Scott RJ,Huzarski T,Byrski T,Masojć B,van de Wetering T,Serrano-Fernandez P,Górski B,Cybulski C,Gronwald J,Debniak B,Maleszka R,Kładny J,Bieniek A,Nagay L,Haus O,Grzybowska E,Wandzel P,Niepsuj S,Narod SA,

更新日期：2006-07-01 00:00:00

abstract：INTRODUCTION:To examine the trends in the prevalence of breast cancer risk factors in relation to breast cancer incidence trends and to explore whether the changes in risk factors differed by ethnicity in Hawaii over a 25-year period. METHODS:We pooled 17 population-based epidemiological studies conducted in Hawaii be...

journal_title：Breast cancer research and treatment

authors： Maskarinec G,Zhang Y,Takata Y,Pagano I,Shumay DM,Goodman MT,Le Marchand L,Nomura AM,Wilkens LR,Kolonel LN

更新日期：2006-07-01 00:00:00

abstract：:While it has been demonstrated that prophylactic mastectomy reduces breast cancer incidence among women at high risk, many women often consider this disfiguring surgery unacceptable. One alternative approach may be breast reduction surgery. In order to evaluate the long-term incidence of breast cancer following surgic...

journal_title：Breast cancer research and treatment

authors： Fryzek JP,Ye W,Nyrén O,Tarone RE,Lipworth L,McLaughlin JK

更新日期：2006-05-01 00:00:00

abstract：:Integrins are cell surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Some of them, e.g. alpha(V)beta(3), alpha(IIb)beta(3) and alpha(2)beta(1), have been suggested as key players for cancer development and tumor metastasis. Two polymorphisms in the gene for the alpha(2) component...

journal_title：Breast cancer research and treatment

authors： Langsenlehner U,Renner W,Yazdani-Biuki B,Eder T,Wascher TC,Paulweber B,Clar H,Hofmann G,Samonigg H,Krippl P

更新日期：2006-05-01 00:00:00

abstract：:The sensitivity of breast neoplasms to hormonal control provides the basis of novel investigational treatments with steroidal alkylators. An androsterone D-lactam steroidal ester, the 3beta-hydroxy-13alpha-amino-13,17-seco- 5alpha-androstan-17-oic-13,17-lactam, p-bis(2-chloroethyl)amino phenyl acetate (lactandrate) wa...

journal_title：Breast cancer research and treatment

authors： Trafalis DT,Geromichalos GD,Koukoulitsa C,Papageorgiou A,Karamanakos P,Camoutsis C

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The aromatase inhibitors (AIs) are increasingly surpassing tamoxifen as the endocrine treatment of choice for postmenopausal breast cancer patients. With their increasing use, there is concern that they are being inadvertently prescribed to pre- and peri-menopausal women. METHODS:As part of a continuing med...

journal_title：Breast cancer research and treatment

authors： Gainford MC,McCready D,Clemons M

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and the propensity to invade dermal lymphatics. In pancreatic cancer, interactions between caveolin-1 and Rho...

journal_title：Breast cancer research and treatment

authors： Van den Eynden GG,Van Laere SJ,Van der Auwera I,Merajver SD,Van Marck EA,van Dam P,Vermeulen PB,Dirix LY,van Golen KL

更新日期：2006-02-01 00:00:00

abstract：:Our aim was to analyze the incidence of mutations in BRCA1 and BRCA2 genes in 54 families with breast/ovarian cancer. Families were selected from three Institutions following the standard criteria for hereditary breast/ovarian cancer. PCR amplification of all exons was performed, followed by SSCP, heteroduplex, PTT an...

journal_title：Breast cancer research and treatment

authors： Gallardo M,Silva A,Rubio L,Alvarez C,Torrealba C,Salinas M,Tapia T,Faundez P,Palma L,Riccio ME,Paredes H,Rodriguez M,Cruz A,Rousseau C,King MC,Camus M,Alvarez M,Carvallo P

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The results of studies comparing survival in familial and sporadic breast cancer (BC) are inconsistent. A higher incidence of contralateral breast cancer (CBC) has been reported in familial BC. Ascertainment bias may influence both the reported familial CBC and survival. DESIGN:We assessed CBC incidence, dista...

journal_title：Breast cancer research and treatment

authors： Tilanus-Linthorst MM,Bartels KC,Alves C,Bakri B,Crepin E,van den Ouweland A,Klijn JG,Meijers-Heijboer H,Brekelmans CT

更新日期：2006-01-01 00:00:00

abstract：:The sentinel lymph node (SLN) is the only focus of axillary metastasis in a significant proportion of patients. In this single institutional study, clinicopathologic characteristics were investigated to determine the factors predicting the status of a SLN biopsy and the metastatic involvement of non-SLNs. Data were re...

journal_title：Breast cancer research and treatment

authors： Ozmen V,Karanlik H,Cabioglu N,Igci A,Kecer M,Asoglu O,Tuzlali S,Mudun A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Estimating an individual woman's absolute risk for breast cancer is essential for decision making about screening and preventive recommendations. Although the current standard, the Gail model, is well calibrated in populations, it performs poorly for individuals. Mammographic breast density (BD) may improve ...

journal_title：Breast cancer research and treatment

authors： Tice JA,Cummings SR,Ziv E,Kerlikowske K

更新日期：2005-11-01 00:00:00

abstract：:Aberrant expressions of the neuronal protein synuclein gamma (SNCG) in malignant mammary epithelial cells are strongly associated with the progression of breast cancer. SNCG is not expressed in normal breast tissues but abundantly expressed in a high percentage of invasive and metastatic breast carcinomas. Several stu...

journal_title：Breast cancer research and treatment

authors： Inaba S,Li C,Shi YE,Song DQ,Jiang JD,Liu J

更新日期：2005-11-01 00:00:00

abstract：:We studied the cost of follow-up of 472 breast cancer patients without distant metastasis after primary treatment in four different schedules in a randomized trial. The mean follow-up was 4.2 years. The four schedules differed in frequency of follow-up visits (every third or sixth month) and in intensity of diagnostic...

journal_title：Breast cancer research and treatment

authors： Kokko R,Hakama M,Holli K

更新日期：2005-10-01 00:00:00

abstract：:As the number of women surviving breast cancer increases, with implications for the health system, research into the physical and psychosocial sequelae of the cancer and its treatment is a priority. This research estimated self-reported health-related quality of life (HRQoL) associated with two rehabilitation interven...

journal_title：Breast cancer research and treatment

authors： Gordon LG,Battistutta D,Scuffham P,Tweeddale M,Newman B

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Long-term endocrine therapy for breast cancer may have clinical implications as drugs that potentially alter the lipid profile may increase the risk of developing cardiovascular disease. In this study, a companion sub-protocol to the TEAM (Tamoxifen and Exemestane Adjuvant Multicenter) International trial,...

journal_title：Breast cancer research and treatment

authors： Markopoulos C,Polychronis A,Zobolas V,Xepapadakis G,Papadiamantis J,Koukouras D,Lappas H,Gogas H

更新日期：2005-09-01 00:00:00

abstract：:Breast cancer has been the most common malignant tumor among women in many large cities of China. The aim of this study was to clarify the prognostic significance of serum anti-p53 antibodies (p53 Abs) in Chinese patients of breast cancer. One hundred and forty-four patients with invasive ductal carcinoma of breast we...

journal_title：Breast cancer research and treatment

authors： Gao RJ,Bao HZ,Yang Q,Cong Q,Song JN,Wang L

更新日期：2005-09-01 00:00:00

abstract：:Estrogen receptor (ER) alpha is a well-established independent prognostic factor in breast cancer whose presence determines the clinical implications of adjuvant endocrine therapy. A second receptor, ERb has been described, and a number of studies have examined its expression in breast tissue. However elucidation of t...

journal_title：Breast cancer research and treatment

authors： Carder PJ,Murphy CE,Dervan P,Kennedy M,McCann A,Saunders PT,Shaaban AM,Foster CS,Witton CJ,Bartlett JM,Walker RA,Speirs V

更新日期：2005-08-01 00:00:00

abstract：:Although there is abundant information about the independent effects of estrogen receptor (ER) and progesterone receptor (PR) on outcomes of breast cancer, comparatively little is known about the impact of joint (ER+PR+, ER+PR-, ER-PR+ and ER-PR-) ERPR expression. The purpose of this study was to evaluate the prognost...

journal_title：Breast cancer research and treatment

authors： Ouyang Y,Li D,Pater JL,Levine M

更新日期：2005-07-01 00:00:00